TRILEPTAL vs CBZ

Reductions in Frequency of Partial Seizures When TRILEPTAL Is Added to Regimens Including or Excluding CBZ1,2

Adult Efficacy Pediatric Efficacy First-line Use TRILEPTAL vs CBZ

	Proven efficacy when added to regimens with CBZ or without CBZ
	Patients were at therapeutic levels of CBZ prior to the addition of TRILEPTAL*1

*Mean level of carbamazepine at baseline: 7.4 μg/mL

Study Limitations

36% of patients in the 1200 mg/day group discontinued therapy due to adverse events2 —  No dosage adjustments were permitted for TRILEPTAL or the concomitant AEDs —  A rapid forced titration schedule, as required by the study protocol, titrated the 1200 mg/day group in 6 days

Reductions in Frequency of Partial Seizures When TRILEPTAL Is Added to Regimens Including or Excluding CBZ^1,3


Multicenter, randomized, double-blind, placebo-controlled trial of 267 children with partial seizures ages 3 to 17 years (n=135 intent-to-treat TRILEPTAL patients). In the 16-week, double-blind phase, patients were randomized to TRILEPTAL 30 to 46 mg/kg/day or to placebo while on their other AEDs. Median dose was 31.4 mg/kg/day.³

	Proven efficacy when TRILEPTAL is added to regimens with CBZ or without CBZ
	Patients were at therapeutic levels of CBZ prior to the addition to TRILEPTAL*1

*Mean level of carbamazepine: 8.1 μg/mL

1.		Data on file, Novartis Pharmaceuticals Corporation.
2.		Barcs G, Walker EB, Elger CE, et al. Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy. Epilepsia. 2000;41:1597-1607.
3.		Glauser TA, Nigro M, Sachdeo R, et al. Adjunctive therapy with oxcarbazepine in children with partial seizures. Neurology. 2000;54:2237-2244.